AB0008 ROLE OF IL-23/TH17 AXIS CYTOKINES IN RHEUMATOID ARTHRITIS

Background Rheumatoid arthritis (RA) is an autoimmune inflammatory driven by cascade of different cytokine families. IL-23/Th17 axis (IL-23, IL-17) has been studied as a key pathway for disease development and its association with severity, joint erosion functional outcome [1], but the data supplementing to support hypothesis lacking conflicting. Also, there paucity on role IL-23/Th17/IL-17 cytokines in Indian subset patients. Objectives The objective was find correlation between serum (IL-17, IL-23) clinical parameters patients, e.g., activity (DAS28) status. Methods This cross-sectional observational study conducted General Medicine OPD from 2021 2022. ACR/EULAR 2010 classification criteria used diagnose RA. Eighty-four consecutive RA patients were recruited after taking consent. Serum IL-17 IL-23 levels measured ELISA method. Clinical laboratory parameters, DAS28-ESR, HAQII recorded. Data analyzed compare subgroups. Results showed higher proportion females than males (n=76,90.5% vs n=8,9.5%). 14.28%(n=12) cases elderly 90.5% cDMARDs, whereas 48.8% (n=41) steroid users. Majority cases, 57.14% (n=48) had high activity, 25% (n=21) moderate activity. Cases achieved remission 5.95%. median value 103.72 pg/ml (IQR=39.91-524.13) 981.87 (IQR=793.25-1205.0), respectively. Swollen count, not tender correlated positively both ( r s =0.229, p=0.036; =0.098, p=0.016, respectively). Among marker, only CRP =0.269, p=0.014). Both insignificant, weak positive DAS28 =0.183, p=0.097 & =0.125, p=0.259), There no difference among severity group (p=0.130 p=0.215). It also noted that =0.221, p=0.044). cytokines, shown statistically status (HAQII) =0.284, p=0.009). level differed significantly (p=0.013). advanced early (p=0.028). Neither nor any subgroup age (younger RA), obesity (obese nonobese), DMARDs or (user naïve), serology (RF+ RF- CCP+ CCP-). Conclusion compared swollen count. Only directly correlating weak, insignificant classes. Even cDMARD/steroid use did affect level. receptor activation triggers transformations acute synovitis chronic persistent [2]. IL-23/IL-17 may be factor advanced/erosive develoment, which need further research. Hence, blocking at stage diminish retard progression disease. References [1]Lubberts E. IL-23-IL-17 arthritis. Nat Rev Rheumatol. 2015 Jul;11(7):415-29. [2]Lubberts E, Schwarzenberger P, Huang W, Schurr JR, Peschon JJ, van den Berg WB, Kolls JK. Requirement signaling radiation-resistant cells full destructive synovitis. J Immunol. 2005 Sep 1;175(5):3360-8. Acknowledgements We thank Dr.Amit Mishra helping analysis. Disclosure Interests None Declared.